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ea0029p988 | Growth hormone IGF axis - basic | ICEECE2012

Plasma ghrelin levels appeared to be elevated in patients with medium-chain acyl-CoA dehydrogenase deficiency and glutaric aciduria type II: evidence for that acyl-CoA is the substrate for ghrelin acylation

Akamizu T. , Sakura N. , Shigematsu Y. , Tajima G. , Ohtake A. , Hosoda H. , Iwakura H. , Ariyasu H. , Kangawa K.

Ghrelin requires a fatty acid modification for binding to the GH secretagogue receptor. Octanoylation of the Ser3 residue of ghrelin is essential for ghrelin-mediated stimulation of GH secretion and regulation of energy homeostasis via increased food intake and adiposity. Other than octanoylation (C8:0), the hormone is subject to other types of acyl modification, decanoylation (C10:0), and possibly decenoylation (C10:1). The fatty acid substrate that contributes to ghrelin acy...

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Endocrine Abstracts

Plasma ghrelin levels appeared to be elevated in patients with medium-chain acyl-CoA dehydrogenase deficiency and glutaric aciduria type II: evidence for that acyl-CoA is the substrate for ghrelin acylation

BiosciAbstracts